With the remit and scope of museum practice changing rapidly in the twenty-first century, this special issue interrogates the role of the museum as a research hub. Recognizing that research has always underpinned museum practice, we invite submissions that address the following concerns: How is research integrated into museums’ future strategies? How do collaborations among researchers, artists, and curators work? What are the key applications of practice-based research? How does publishing contribute to research culture? We also encourage submissions that discuss examples of best practices.